
法国Salpêtrière医院心律研究所主任
早在1966年, Fontaine教授就因其在“电刺激对人心脏的作用”研究领域中的卓越成就取得博士学位,此后他在心电现象相关知识使心脏起搏特别是自动夺获技术取得了长足进展。1967年,Fontaine教授在巴黎完成了世界上首例采用心内电极的永久起搏器植入术。1976年Fontaine博士出版了专著《心脏起搏必读》,编者中还有他的导师Grosgogeat和同事Welti等人,该书曾先后被译成英语、德语和西班牙语版本。
受外科手术消融旁路治疗预激综合征的初次尝试所启发,在与Guiraudon博士合作经过长达六个月的实验研究后,Fontaine博士攻克了心外膜标测技术这一难题。借助于该技术,在欧洲完成了首例旁路外科消融治疗。Fontaine教授应用这种可操控导管在外科手术中标测室速患者的折返环,他所在的研究团队首次应用“简化的心室肌离断术”阻断折返旁路并预防室颤复发。
Fontaine博士曾提议应用“致心律失常性右室发育不良”描述年轻患者中出现的室速其右室正常的心肌组织被脂肪和纤维组织替代的情况。该病及其变异类型被越来越多的认识,1996年WHO组织将其纳入最新的心疾病分类中。
Fontaine博士于1996年在巴黎组织召开了第一届“国际右室发育不良研讨会”并担任该次会议的大会主席。因为已认识到该病有遗传倾向,所以会议的重要议题是如何确定猝死风险或如何明确猝死高危家系。在此基础之上,Fontaine博士率先在法国倡导进行对右室心肌病患者进行登记注册,其后这项工作在欧洲和美国也相继开展。
Fontaine博士对应用直流电消融的机制也进行了深入的研究,并于1991年发表了题为“电灼伤治疗物理学、生理学、电生理学的效应及其在心律失常治疗中的应用”的论文,其突出的成绩获得Orsay大学奖。Fontaine博士致力于心律失常的导管消融治疗,尤其对室性心律失常的研究颇有建树,并在美国多个实验室担任室性心律失常的研究指导工作。
Fontaine博士发表的论文达823篇之多,其中英文文章(包括综述)占425篇。823篇论文中有213篇被选引入著作中,其中150篇出现在英文版著作中。Fontaine博士出版的5部著作中涉猎心电图学和心电生理学的不同领域。
Fontaine博士是美国2005年度“Legion奖”的5位获奖者之一。
英文简历:
Guy Fontaine, MD, PhD
Research Director, Institut de Cardiologie – Unité de Rythmologie
H?pital de la Salpêtrière – 47 Bld de l’Hopital – 75013 PARIS - FRANCE
In 1966, he received his doctoral degree with high distinction for his work entitled “Contributions to electrical stimulation of the human heart”. Later he used his knowledge of electrical phenomena to make significant advances in pacemaker technology such as an auto-capture device. In 1967, he was the first to implant permanent pacemakers using intracardiac leads in Paris. In 1976, he published the book “The Essentials of Cardiac Pacing”, co-authored with his mentors and colleagues, Professor Y Grosgogeat and JJ Welti, which was later translated from French into English, German and Spanish.
Dr. Fontaine was fascinated by the first surgical attempts to ablate the accessory bypass tract in the WPW syndrome. After six months of work in the experimental laboratory with Dr Guiraudon, he developed in Paris his technique of epicardial mapping. This led to the first European successful surgical ablation of an accessory pathway. Using the same hand held probe that was previously used for mapping the accessory bypass tract, Drs. Fontaine began to map the reentrant circuits in patients with ventricular tachycardias during surgery. This group demonstrated for the first time the interruption of the reentrant pathway and prevention of its recurrence with a “simple ventriculotomy”.
It was during this phase of his work that Dr. Fontaine suggested the term of “Arrhythmogenic Right Ventricular Dysplasia” (ARVD) to describe a new clinical entity found in young patients with ventricular tachycardia originating in the right ventricle showing severe replacement of myocardial tissue by fat and fibrosis. This disease and its variants is being more frequently recognized and is now included in the latest classification of cardiomyopathies proposed by the World Health Organization in 1996.
He was President and organizer of the First International Symposium devoted to right ventricular dysplasia held in Paris in 1996. Since it is known that this disease is genetic in some patients, the problem of how to define the risk of sudden death or identification of this condition in family members has come to the forefront. This and other considerations have led Dr. Fontaine to initiate a French registry of right ventricular cardiomyopathies followed by the European Community registry (G. Thiene) in collaboration with the American registry (F. Marcus).
Dr. Fontaine also did extensive research to help understand ablation using direct current energy. This led to a doctoral thesis in sciences awarded with “high distinction” from the University of Orsay in 1991. The title of this Thesis was “Physical, Biophysical and Electrophysiological Effects of Fulguration : Application to the Treatment of Cardiac Arrhythmias”. He is frequently sought for his expertise in catheter ablation of cardiac arrhythmias, especially for ventricular tachycardia, and has participated as a consultant on this procedure in a number of laboratories in the United States.
He is the author of more than 823 scientific articles of which 425 are written in English (including peer reviewed abstracts). Among the 823 articles, there are 213 book chapters of which 150 have been published in English. He is the author of five books on different subjects of Electrocardiography or Electrophysiology.
He has been one of the five awardees of the American “Legion of Honor” for the year 2005.
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