关键词：2008WCHD 14届世界心脏病大会 心力衰竭

      最近，我们已经采用大型基因表达谱对与冠心病发展和回归有关的新型基因的差异表达做出鉴定。在二期验证中，我们已经使用从大鼠和人类身上分别获得衰竭和不衰竭的心脏组织，并且通过基因手段和外科手段（挽救）心脏表型。以已经在这些研究中鉴定出的基因为基础，我们正在进行三项主要的科研项目。通过使用遗传工程大鼠再加上外科心力衰竭模型，我们证实了在心力衰竭特定的发病时期这些基因中每一成员的重要作用。全球性的关于发现和验证新的诊断和治疗心力衰竭靶点基因的探讨即将提上日程。

We have recently identified differential expression of a number of novel genes associated with both the development and regression of cardiac disease by large-scale gene expression profiling.  We have used both mouse and human heart tissue from non-failing, failing, and genetically or surgically "rescued" cardiac phenotypes, followed by secondary validation.  We are pursuing three main projects based largely on genes identified in these studies.  Using genetically engineered mice coupled with surgical models of heart failure, we demonstrate an important role for each of these genes at particular stages of the pathogenesis of heart failure.  The global approach of finding and validating new diagnostic and therapeutic target genes for heart failure will be discussed

来自第14届世界心脏病大会
张伟译 刘琳宁校